The Origins of Genome Architecture
by Michael Lynch
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Book Summary Information
Author: Michael LynchEdition: Hardcover
Published: 2007-03-30
ISBN: 0878934847
Number of pages: 340
Publisher: Sinauer Associates Inc
Book Reviews of The Origins of Genome Architecture
Book Review: Original view on evolution
Summary: 4 Stars
This book offers a non-conventional view on biological evolution, particularly that of animals, including humans. Solid molecular and population genetic analysis reveal that evolution of higher eukaryotes are realised predominantly by genetic drift of pseudo neutral mutations rather than by Darwinian type selection mechanisms. Authors' concept also might be applied to explain so far less discussed issue on the direction of evolution - from primitive forms towards more developed organisms.
Summary of The Origins of Genome Architecture
With official genomic blueprints now available for hundreds of species, and thousands more expected in the near future, the field of biology has been forever transformed. Such readily accessible data have encouraged the proliferation of adaptive arguments for the evolution of gene and genomic features, often with little or no attention being given to simpler and more powerful alternative explanations. By integrating the central observations from molecular biology and population genetics relevant to comparative genomics, Lynch shows why the details matter.Presented in a nontechnical fashion, at both the population-genetic and molecular-genetic levels, this book offers a unifying explanatory framework for how the peculiar architectural diversity of eukaryotic genomes and genes came to arise. Under Lynch's hypothesis, the genome-wide repatterning of eukaryotic gene structure, which resulted primarily from nonadaptive processes, provided an entirely novel resource from which natural selection could secondarily build new forms of organismal complexity.
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