As the Orient Express hurtles across Europe on its three-day journey from Ostend to Constantinople, the driven lives of several of its passengers become bound together in a fateful interlock. The menagerie of characters include Coral Musker, a beautiful chorus girl; Carleton Myatt, a rich Jewish businessman; Richard John, a mysterious and kind doctor returning to his native Belgrade; the spiteful journalist Mabel Warren; and Josef Grunlich, a cunning, murderous burglar.

What happens to these strangers as they put on and take off their masks of identity and passion, all the while confessing, prevaricating, and reaching out to one another in the "veracious air" of the onrushing train, makes for one of Graham Greene's most exciting and suspenseful stories. Originally published in 1933, Orient Express was Greene's first major success.